Research Interests
Current Research Interests:
My clinical and research interests center on the prevention of the chronic diseases of ageing, of which atherosclerosis is perhaps the best studied. In particular, I am fascinated by the myriad of protective effects of endurance exericse (e.g., running, cycling, rowing, swimming, etc). Despite the well-known positive effects of exercise, little is known regarding the molecular mechanisms and pathways through which they exert their cardioprotective effects. To that end, I am working on several projects to better characterize the molecular response of specific cell types to acute endurance exercise and chronic endurance exercise training. Separately, I am working on efforts to bridge my current and prior research interests by similar assessing how endurance exercise affects cardiometabolic traits.
Representative Publications:
Kim DS, Wheeler MT, Ashley EA. The Genetics of Human Performance. Nat Rev Genet. 2021 Sep 14. doi: 10.1038/s41576-021-00400-5.
Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021 Aug 3;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346.
Kim DS and Khandelwal A. Lipoprotein(a) and Incident Atrial Fibrillation: Leveraging Nature’s Randomization to Identify Novel Causal Associations. 2022 Apr 26;79(16):1591-1593. doi: 10.1016/j.jacc.2022.02.026. PMID: 35450576.
Prior Research Interests:
Atherosclerotic Cardiovascular Disease
During my PhD, I worked on projects related to high-density lipoprotein (HDL) associated proteins, such as paraoxonase-1 (PON1) and phospholipid transplant protein (PLTP), that have cardioprotective effects independent of HDL. In light of the failure of HDL cholesterol raising medications to improve cardiovascular outcomes (and similar failures in Mendelian randomization), I argued for more precise, focused sub-phenotyping of HDL to hone in on the specific components of the complex HDL particle that bely its traditionally held cardioprotective effects.
Representative Publications
Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth WT Jr, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP; on behalf of the NHLBI Exome Sequencing Project. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res. 2014 Apr 7;55(6):1173-1178. PubMed PMID: 24711634; PubMed Central PMCID: PMC4031948.
Kim DS, Li YK, Bell GA, Burt AA, Vaisar T, Hutchins PM, Furlong CE, Otvos JD, Polak JF, Arnan MK, Kaufman JD, McClelland RL, Longstreth WT Jr, Jarvik GP. Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA). J Am Heart Assoc. 2016 May 20;5(5). pii: e002977. doi: 10.1161/JAHA.115.002977. PMID: 27207961.
Kim DS, Jackson AU, Li YK, Stringham HM, FinMetSeq Investigators, Kuusisto J, Kangas AJ, Soininen P, Ala-Korpela M, Burant CF, Salomaa V, Boehnke M, Laakso M, Speliotes EK. Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns. J Lipid Res. 2017 Jul;58(7):1471-1481. doi: 10.1194/jlr.P076034. Epub 2017 May 24. PMID: 28539357.
Review on HDL Genetics and Systems Biology (pdf)
Congenital Heart Disease and its Sequelae
Congenital heart disease (CHD) requiring surgical intervention with bypass results in impaired neurodevelopment in children. In addition, there is a high long-term mortality rate among children with CHD. For my MPH work in Biostatistics, I worked on projects to identify genetic modifiers of ischemia-mediated neurodevelopmental problems and separately, genetic predictors of survival in these high-risk patients.
Representative Publications
Kim DS, Kim JH, Burt AA, Crosslin DR, Burnham N, McDonald-McGinn DM, Zackai EH, Nicolson SC, Spray TL, Stanaway IB, Nickerson DA, Russell MW, Hakonarson H, Gaynor JW, Jarvik GP. Patient genotypes impact survival after surgery for isolated congenital heart disease. Ann Thorac Surg. 2014 Jul;98(1):104-11. doi: 10.1016/j.athoracsur.2014.03.017. Epub 2014 May 6. PubMed PMID: 24811984; PubMed Central PMCID: PMC4083015.
Kim DS, Kim JH, Burt AA, Crosslin DR, Burnham N, Kim CE, McDonald-McGinn DM, Zackai EH, Nicolson SC, Spray TL, Stanaway IB, Nickerson DA, Heagerty PJ, Hakonarson H, Jarvik GP, Gaynor JW. Burden of potentially pathologic copy number variants is higher in children with isolated congenital heart disease and significantly impairs covariate-adjusted transplant-free survival. J Thorac Cardiovasc Surg. 2015. 2015 Nov 10. pii: S0022-5223(15)02208-4. doi: 10.1016/j.jtcvs.2015.09.136. PMID: 26704054.
Kim DS, Li YK, Kim JH, Bergquist C, Gerdes M, Bernbaum JC, Burnham N, McDonald-McGinn DM, Zackai EH, Nicolson SC, Spray TL, Hakonarson H, Jarvik GP, Gaynor JW. Autosomal Dominant Mannose-Binding Lectin (MBL) Deficiency is Associated with Worse Neurodevelopmental Outcomes After Cardiac Surgery in Infants. J Thorac Cardiovasc Surg. J Thorac Cardiovasc Surg. 2018 Mar;155(3):1139-1147.e2. doi: 10.1016/j.jtcvs.2017.08.035. PMID: 29452463.